Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756–60. Google Scholar | Crossref |

Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease.

investigate reciprocal signaling between glioma stem cells and their differentiated glioblastoma cell progeny. The authors demonstrate that differentiated tumor cells promote the glioblastoma hierarchy and tumor growth through a paracrine feedback loop of neurotrophin signaling in cooperation with stem cell-like tumor cells. This consideration together with the observation that glioma stem cells reside preferentially in specific niches (Zeppernick et al., 2008; Calabrese et al., 2007; Li et al., 2009; Christensen et al., 2008) leads to our proposal that radioresistance is more likely to be a property of the ‘microenvironment‐stem cell unit’, a functional entity within which glioma stem cells are able to Bao, S., Wu, Q., McLendon, R.E., Hao, Y., Shi, Q., Hjelmeland, A.B., Dewhirst, M.W., Bigner, D.D. and Rich, J.N. (2006) Glioma Stem Cells Promote Radioresistance by Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60. Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. Cancer stem cells contribute to glioma radioresistance by an increase of DNA repair capacity through preferential activation of the DNA damage response checkpoints.

8 Oct 2007 Our DNA is packaged in chromosomes, which occur in pairs – one Smithies initially tried to repair mutated genes in human cells. Embryonic stem cells – vehicles to the mouse germ line It is now possible to introd

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 2019-08-27 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. S Bao, Q Wu, RE McLendon, Y Hao, Q Shi, AB Hjelmeland,

cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Thus, tumours sur- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines.

Nature. 2006;444(7120):756–60. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. S Bao, Q Wu, RE McLendon, Y Hao, Q Shi, AB Hjelmeland, The ability to prospectively distinguish glioma stem cells, which reside at the Similarly, glioma CSCs preferentially express the IL-6 receptor, which also promotes Cancer cells often activate redundant angiogenic pathways in res Collectively, glioblastoma offers a reliable cancer to study cancer stem cells (A) Critical epigenetic regulators drive GSC maintenance and response to cells promote radioresistance by preferential activation of the DNA damage res 21 Jun 2019 The cellular response to DNA damage is a complex process Rich, J.N. Glioma stem cells promote radioresistance by preferential activation of 1 Sep 2018 A consistent feature of the GSC and cancer stem cell DDR phenotype is the upregulation and/or constitutive activation of multiple components of both the DNA repair radiation resistance in relatively radiosensitive non-G brain tumors select for and induce a more stem-like population of cells that can activation of the DNA damage response. The CD133+ Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
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Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Thus, tumours sur- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures.

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage The blue social bookmark and publication sharing system. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
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21 Jun 2019 The cellular response to DNA damage is a complex process Rich, J.N. Glioma stem cells promote radioresistance by preferential activation of

24 Mar 2021 Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444(7120):756–60.

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Cancer stem cells contribute to glioma radioresistance by an increase of DNA repair capacity through preferential activation of the DNA damage response checkpoints. Potential therapies that modulate or target cancer stem cells are also reviewed.

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … 2018-05-21 · Previous studies showed that, preferential activation of the DNA damage checkpoint and enhanced DNA repair capacity in gliomas lead to radioresistance [9, 14, 15]. Strategies depending on targeting DNA damage response network in gliomas were applied to sensitize tumors and reverse radioresistance [16, 17].